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M94A3163.TXT
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1994-10-25
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Document 3163
DOCN M94A3163
TI Is there any receptor other than CD4 essential for HIV-1 infection?
DT 9412
AU Furlini G; Re MC; Vignoli M; Ramazzotti E; Monari P; La Placa M;
Institute of Microbiology, University of Bologna, St. Orsola; Hospital,
Italy.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):139 (abstract no. PA0175). Unique
Identifier : AIDSLINE ICA10/94369412
AB OBJECTIVE: The present work aimed to elucidate whether human
hematopoietic progenitor cells show substantial and significant
difference on the presence of membrane molecules in comparison with
HIV-1 susceptible cell lines, to verify whether the lack of
infectability of progenitor cells, despite CD4 presence, may be related
with the absence of other cofactors, present on susceptible cells.
METHODS: We screened, by means of cytofluorimetric analysis, the
presence of several membrane proteins (cellular adhesion molecule as
ICAM, LECAM, HCAM, VLA and other integrin subfamilies, etc.) on CD34+
cells isolated from bone marrow (BM-CD34+) of healthy subjects and a
CD34+ cell line (TF-1) in comparison to PBL and three cell lines (H9,
Jurkat and A3.01) susceptible to HIV-1 infection. RESULTS: Results
obtained clearly point out that the presence or the absence of such
membrane molecules doesn't seem to play a role on the susceptibility and
lack of susceptibility of all the cells tested. One exception could be
represented by the CD11a molecule that showed a possible intervention on
virus entry in sensitive cells. DISCUSSION AND CONCLUSIONS: In this work
we have shown the lack of significant differences on the distribution of
the various molecules studied among HIV susceptible and unsuceptible
cells, with the possible exception of CD11a. Our data lead to the idea
that other surface protein(s) having such cooperating function in viral
entry must be taken into consideration.
DE Acquired Immunodeficiency Syndrome/*MICROBIOLOGY Antigens,
CD/*PHYSIOLOGY Antigens, CD4/*PHYSIOLOGY Cell Adhesion
Molecules/*PHYSIOLOGY Cell Line Cell Membrane/IMMUNOLOGY Comparative
Study Flow Cytometry/METHODS Human HIV-1/*PHYSIOLOGY
Integrins/*PHYSIOLOGY Lymphocytes/*IMMUNOLOGY Receptors,
Virus/*PHYSIOLOGY Reference Values MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).